【药物名称】Wy-50295
化学结构式(Chemical Structure):
参考文献No.803830
标题:Conversion of a cyclooxygenase (CO) inhibitor into a 5-lipoxygenase (LO) inhibitor - A general route to novel antiinflammatory and antiallergy drugs
作者:Kreft, A.F.; Failli, A.; Musser, J.H.; et al.
来源:Drugs Exp Clin Res 1991,17381-387
合成路线图解说明:

By condensation of 1-naphthol (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

合成路线图解说明:

By condensation of 2(S)-(6-hydroxy-2-naphthyl)propionic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

合成路线图解说明:

By condensation of 2-(2-fluoro-4'-hydroxybiphenyl-4-yl)acetic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

参考文献No.803831
标题:Structure -activity relationships in the quinoline- containing class of inhibitors of 5-lipoxygenase (5-LO) enzyme translocation and activation
作者:Marshall, L.A.; Wong, A.; Kreft, A.F.
来源:Drugs Fut 1994,19(3),255
合成路线图解说明:

By condensation of 1-naphthol (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

合成路线图解说明:

By condensation of 2(S)-(6-hydroxy-2-naphthyl)propionic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

合成路线图解说明:

By condensation of 2-(2-fluoro-4'-hydroxybiphenyl-4-yl)acetic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

参考文献No.803850
标题:Substituted-[2-Quinolinyl(Bridged)Aryl] compounds: Modulators of eicosanoid biosynthesis and action
作者:Kreft, A.; Musser, J.
来源:Drugs Fut 1990,15(1),73
合成路线图解说明:

By condensation of 2(S)-(6-hydroxy-2-naphthyl)propionic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

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