【药物名称】Cimadronate sodium, Incadronic acid sodium salt, YM-175, YM-21175-1, Bisphonal
化学结构式(Chemical Structure):
参考文献No.10873
标题:(Cycloalkylamino)methylenebisphosphonic acids and medicines containing them
作者:Isomura, Y.; Takeuchi, M.; Sakamoto, S.; Abe, T. (Yamanouchi Pharmaceutical Co., Ltd.)
来源:AU 8928670; EP 0325482; JP 1989308290; US 5041428
合成路线图解说明:

The reaction of cycloheptylamine (I) with triethyl orthoformate (II) and diethyl phosphite (III) at 150 gives cycloheptylaminomethylenediphosphonic acid tetraethyl ester (IV), which is then hydrolyzed with refluxing concentrated hydrochloric acid.

参考文献No.144603
标题:Synthesis and structure-activity relationships of a novel anti-resorptive agent YM175, and the related derivatives
作者:Takeuchi, M.; Sakamoto, S.; Kawamuki, K.; Kudo, M.; Murase, K.; Kawashima, H.; Isomura, Y.
来源:Symp Med Chem 1990,P-12
合成路线图解说明:

The reaction of cycloheptylamine (I) with triethyl orthoformate (II) and diethyl phosphite (III) at 150 gives cycloheptylaminomethylenediphosphonic acid tetraethyl ester (IV), which is then hydrolyzed with refluxing concentrated hydrochloric acid.

参考文献No.172527
标题:YM-175
作者:Prous, J.; Casta馿r, J.
来源:Drugs Fut 1992,17(4),293
合成路线图解说明:

The reaction of cycloheptylamine (I) with triethyl orthoformate (II) and diethyl phosphite (III) at 150 gives cycloheptylaminomethylenediphosphonic acid tetraethyl ester (IV), which is then hydrolyzed with refluxing concentrated hydrochloric acid.

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