He-30582-药物合成数据库

【药物名称】He-30582

化学结构式(Chemical Structure):

参考文献No.	11470
标题:	6-Oxo-pyridazinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
作者:	Herter, R.; Engler, H.; Pfahlert, V.; Weidner, R.; Ahrens, K.H. (Heumann Pharma GmbH & Co.)
来源:	DE 3814057

合成路线图解说明: The acylation of 5-methyl-6-[3-nitro-4-(piperazin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone (I) with benzoyl isothiocyanate gives the benzoylthiourea (II), which is cleaved by alkaline hydrolysis with potassium carbonate and methylated with methyl iodide to the isothiouronium salt (III). This compound is condensed with 3-(1H-imidazol-4-yl)propylamine (homohistamine, IV) to yield title compound.

参考文献No.	109648
标题:	HE 30582
作者:	M鰎sdorf, P.; Engler, H.
来源:	Drugs Fut 1989,14(12),1161

合成路线图解说明: The acylation of 5-methyl-6-[3-nitro-4-(piperazin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone (I) with benzoyl isothiocyanate gives the benzoylthiourea (II), which is cleaved by alkaline hydrolysis with potassium carbonate and methylated with methyl iodide to the isothiouronium salt (III). This compound is condensed with 3-(1H-imidazol-4-yl)propylamine (homohistamine, IV) to yield title compound.