BI-L-226-药物合成数据库

【药物名称】BI-L-226

化学结构式(Chemical Structure):

参考文献No.	155161
标题:	2,6-Disubstituted-4-(2-arylethenyl)phenol 5-lipoxygenase inhibitors: Development and profile of BI-L-239
作者:	Lazer, E.S.; Farina, P.R.; Gundel, R.H.; Wegner, C.D.
来源:	Drugs Fut 1991,16(7),641

合成路线图解说明: The reaction of 2,6-di-tert-butyllphenol (I) with hexamethylenetetramine (HMT) and sulfuric acid in ethyleneglycol at 130 C gives 4-hydroxy-3,5-di-tert-butylbenzaldehyde (II), which is finally condensed with 2-(3-pyridyl)acetic acid (III) by means of piperidine in dichloromethane at 130 C.

合成路线图解说明: The reaction of 2,6-dimethylphenol (I) with hexamethylenetetramine (HMT) and sulfuric acid in ethyleneglycol at 130 C gives 4-hydroxy-3,5-dimethylbenzaldehyde (II), which is finally condensed with 2-(2-thienyl)acetic acid (III) by means of piperidine in dichloromethane at 130 C.

合成路线图解说明: The reaction of 2,6-dimethylphenol (I) with hexamethylenetetramine (HMT) and sulfuric acid in ethyleneglycol at 130 C gives 4-hydroxy-3,5-dimethylbenzaldehyde (II), which is finally condensed with 2-(4-fluorophenyl)acetic acid (III) by means of piperidine in dichloromethane at 130 C.