【药物名称】Neridronate, Neridronic acid, AHHexBP, Nerixia
化学结构式(Chemical Structure):
参考文献No.23712
标题:Process for the preparation of diphosphonic acids and salts thereof
作者:Guainai-Ricci, G.; Rosini, S. (Istituto Gentili SpA)
来源:EP 0494844
合成路线图解说明:

The target product is obtained by phosphorylation of aminocaproic acid (I) by reflux with PCl3 / phosphorous acid (H3PO3) (directly or in chlorobenzene), followed by hydrolysis with boiling H2O.

参考文献No.53038
标题:Process for the preparation of diphosphonic acids
作者:Staibano, G. (Istituto Gentili SpA)
来源:US 4705651
合成路线图解说明:

The target product is obtained by phosphorylation of aminocaproic acid (I) by reflux with PCl3 / phosphorous acid (H3PO3) (directly or in chlorobenzene), followed by hydrolysis with boiling H2O.

参考文献No.53039
标题:Process for the production of omega-amino-1-hydroxyalkylidene-1,1-bisphosphonic acid
作者:Blum, H.; Worms, K.-H. (Henkel KgA)
来源:US 4407761
合成路线图解说明:

The target product is obtained by phosphorylation of aminocaproic acid (I) by reflux with PCl3 / phosphorous acid (H3PO3) (directly or in chlorobenzene), followed by hydrolysis with boiling H2O.

参考文献No.900161
标题:
作者:
来源:US 4304734
合成路线图解说明:

The target product is obtained by phosphorylation of aminocaproic acid (I) by reflux with PCl3 / phosphorous acid (H3PO3) (directly or in chlorobenzene), followed by hydrolysis with boiling H2O.

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