Pikamilone-药物合成数据库

【药物名称】Pikamilone

化学结构式(Chemical Structure):

参考文献No.	114546
标题:	PIKAMILONE
作者:	Rejholec, V.
来源:	Drugs Fut 1990,15(2),133

合成路线图解说明: Nicotinic acid azide (I) is mixed with a solution of gamma-aminobutyric acid (II) in 1 N NaOH (pH 8-9). The mixture is stirred for 24 hours, evaporated and the residue is washed with methanol. The resultant sodium salt of nicotinoyl-gamma-aminobutyric acid is then dried. It can be further converted to nicotinoyl-gamma-aminobutyric acid (III) by dissolving in a minimum amount of water and adjusting pH to 3.5.

参考文献No.	900002
标题:	Process for the preparation of N-nicotinoyl-gamma-aminoaliphatic acids or its esters
作者:	Kopelevich, V.M.; Trubnikov, V.I.; Shmvilovich, L.M.; et al. (USSR Res. Inst. Vitamins)
来源:	SU 325232

合成路线图解说明: Nicotinic acid azide (I) is mixed with a solution of gamma-aminobutyric acid (II) in 1 N NaOH (pH 8-9). The mixture is stirred for 24 hours, evaporated and the residue is washed with methanol. The resultant sodium salt of nicotinoyl-gamma-aminobutyric acid is then dried. It can be further converted to nicotinoyl-gamma-aminobutyric acid (III) by dissolving in a minimum amount of water and adjusting pH to 3.5.