【药物名称】LY-267108
化学结构式(Chemical Structure):
参考文献No.133153
标题:Synthesis of ring-contracted derivatives of erythromycin
作者:Kirst, H.A.; Wind, J.A.; Paschal, J.W.
来源:J Org Chem 1987,52(19),4359-62
合成路线图解说明:

Intramolecular cyclization of erythromycin A (I) under acidic conditions yields its 8,9-anhydro-6,9-hemiketal derivative (II). Subsequent intramolecular trans-lactonization of (II) under basic conditions produces the ring-contracted compound, LY267108. It has also been synthesized from erythromycin in a single step by heating the latter in a 3:1 mixture of pyridine and acetic acid.

参考文献No.133155
标题:Identification of novel erythromycin derivatives in mother liquor concentrates of Streptomyces erythraeus
作者:Kibwage, I.O.; Janssen, G.; Busson, R.; Hoogmartens, J.; Vanderhaeghe, H.; Verbist, L.
来源:J Antibiot 1987,40(1),1-6
合成路线图解说明:

Intramolecular cyclization of erythromycin A (I) under acidic conditions yields its 8,9-anhydro-6,9-hemiketal derivative (II). Subsequent intramolecular trans-lactonization of (II) under basic conditions produces the ring-contracted compound, LY267108. It has also been synthesized from erythromycin in a single step by heating the latter in a 3:1 mixture of pyridine and acetic acid.

参考文献No.133158
标题:Translactonization in erythromycins
作者:Janssen, G.; Hoogmartens, J.; Kibwage, I.O.; Vanderhaeghe, H.; Bracke, J.; Busson, R.
来源:J Org Chem 1987,52(6),990-6
合成路线图解说明:

Intramolecular cyclization of erythromycin A (I) under acidic conditions yields its 8,9-anhydro-6,9-hemiketal derivative (II). Subsequent intramolecular trans-lactonization of (II) under basic conditions produces the ring-contracted compound, LY267108. It has also been synthesized from erythromycin in a single step by heating the latter in a 3:1 mixture of pyridine and acetic acid.

参考文献No.161389
标题:LY267108
作者:Kirst, H.A.; Greenwood, B.; Gidda, J.S.
来源:Drugs Fut 1992,17(1),18
合成路线图解说明:

Intramolecular cyclization of erythromycin A (I) under acidic conditions yields its 8,9-anhydro-6,9-hemiketal derivative (II). Subsequent intramolecular trans-lactonization of (II) under basic conditions produces the ring-contracted compound, LY267108. It has also been synthesized from erythromycin in a single step by heating the latter in a 3:1 mixture of pyridine and acetic acid.

参考文献No.802386
标题:Acid degradation of erythromycin A and erythromycin B
作者:Kurath, P.; Egan, R.S.; Jones, P.H.; Perun, T.J.
来源:Experientia 1971,27(4),362
合成路线图解说明:

Intramolecular cyclization of erythromycin A (I) under acidic conditions yields its 8,9-anhydro-6,9-hemiketal derivative (II). Subsequent intramolecular trans-lactonization of (II) under basic conditions produces the ring-contracted compound, LY267108. It has also been synthesized from erythromycin in a single step by heating the latter in a 3:1 mixture of pyridine and acetic acid.

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