【药物名称】TNP-470, AGM-1470
化学结构式(Chemical Structure):
参考文献No.12200
标题:Fumagillol derivs
作者:Kishimoto, S.; Fujita, T. (Takeda Chemical Industries, Ltd.)
来源:EP 0359036; EP 0682020; JP 1991007270; US 5164410; US 5166172; US 5180738; US 5698586
合成路线图解说明:

By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.

参考文献No.14334
标题:Cyclohexanol derivs., production and use thereof
作者:Kishimoto, S.; Marui, S.; Fujita, T. (Takeda Chemical Industries, Ltd.)
来源:EP 0415294; JP 1991279376; US 5180735
合成路线图解说明:

By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.

参考文献No.186486
标题:Chemical modification of fumagillin. I. 6-O-Acyl, 6-O-sulfonyl, 6-O-alkyl, and 6-O-(N-substituted-carbamoyl)fumagillols
作者:Marui, S.; Itoh, F.; Kozai, Y.; Sudo, K.; Kishimoto, S.
来源:Chem Pharm Bull 1992,40(1),96-101
合成路线图解说明:

By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.

参考文献No.268232
标题:AGM-1470
作者:Mealy, N.; Prous, J.; Casta馿r, J.
来源:Drugs Fut 1994,19(11),981
合成路线图解说明:

By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.

参考文献No.900018
标题:Angiogenesis inhibitory agent
作者:Fujita, T.; Kanamaru, T.; Folkman, M.; Ingber, D. (Children's Med. Cent. Corp.; Takeda Chemical Industries, Ltd.)
来源:EP 0357061
合成路线图解说明:

By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.

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