Mofegiline hydrochloride, MDL-72974A-药物合成数据库

【药物名称】Mofegiline hydrochloride, MDL-72974A

化学结构式(Chemical Structure):

参考文献No.	137103
标题:	MDL-72,974A
作者:	McDonald, I.A.; Bey, P.; Zreika, M.; Palfreyman, M.G.
来源:	Drugs Fut 1991,16(5),428

合成路线图解说明: The key steps in the synthesis of MDL-72,974A were the conversion of (II) to (IV). Treatment of the malonate (II) with sodium tert-butoxide followed by ClCHF2 afforded the difluoromalonate (III), which was selectively deprotected with CF3CO2H, then reacted with base to stereoselectively yield (E)-(IV). Elaboration of (IV) to MDL-72,974A followed standard procedures; the final product was purified via the N-BOC derivative.

参考文献No.	607710
标题:	Enzyme-activated irreversible inhibitors of monoamine oxidase: Phenylallylamine structure-activity relationships
作者:	McDonald, I.A.; Lacoste, J.M.; Bey, P.; Palfreyman, M.G.; Zreika, M.
来源:	J Med Chem 1985,28(2),186-93

合成路线图解说明: The key steps in the synthesis of MDL-72,974A were the conversion of (II) to (IV). Treatment of the malonate (II) with sodium tert-butoxide followed by ClCHF2 afforded the difluoromalonate (III), which was selectively deprotected with CF3CO2H, then reacted with base to stereoselectively yield (E)-(IV). Elaboration of (IV) to MDL-72,974A followed standard procedures; the final product was purified via the N-BOC derivative.