【药物名称】Aripiprazole, OPC-31, OPC-14597, Abilify, Abilitat
化学结构式(Chemical Structure):
参考文献No.12388
标题:Carbostyril derivs
作者:Oshiro, Y.; Sato, S.; Kurahashi, N. (Otsuka Pharmaceutical Co., Ltd.)
来源:EP 0367141; JP 1990191256; JP 1995304740; JP 1995304741; US 5006528
合成路线图解说明:

By condensation of 7-(4-bromobutoxy)-1,2,3,4-tetrahydroquinolin-2-one (I) with 1-(2,3-dichlorophenyl)piperazine (II) by means of NaI and triethylamine in refluxing acetonitrile.

参考文献No.314641
标题:OPC-14597
作者:Casta馿r, J.; Mealy, N.; Rabasseda, X.
来源:Drugs Fut 1995,20(9),884
合成路线图解说明:

By condensation of 7-(4-bromobutoxy)-1,2,3,4-tetrahydroquinolin-2-one (I) with 1-(2,3-dichlorophenyl)piperazine (II) by means of NaI and triethylamine in refluxing acetonitrile.

参考文献No.472996
标题:Novel antipsychotic agents with dopamine autoreceptor agonist properties: Synthesis and pharmacology of 7-[4-(4-phenyl-1-piperazinyl)butoxy]-3, 4-dihydro-2(1H)-quinolinone derivatives
作者:Oshiro, Y.; Sato, S.; Kurahashi, N.; Tanaka, T.; Kikuchi, T.; Tottori, K.; Uwahodo, Y.; Nishi, T.
来源:J Med Chem 1998,41(5),658
合成路线图解说明:

The condensation of 7-hydroxy-1,2,3,4-tetrahydroquinolin-2-one (I) with 1,4-dibromobutane (II) by means of K2CO3 in hot DMF gives 7-(4-bromobutoxy)-1,2,3,4-tetrahydroquinolin-2-one (III), which is then condensed with 1-(2,3-dichlorophenyl)piperazine (IV) by means of NaI and triethylamine in refluxing acetonitrile.

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