Nepinalone, Tussolvina(hydrochloride)-药物合成数据库

【药物名称】Nepinalone, Tussolvina(hydrochloride)

化学结构式(Chemical Structure):

参考文献No.	13168
标题:	Novel 1,2,3,4-tetrahydronaphthalen-2-ones and a process for the preparation thereof
作者:	Fusco, R.; Tenconi, F. (Pfizer Inc.)
来源:	GB 1140990; US 3576811

合成路线图解说明: Friedel-Crafts condensation of 2-phenylpropionyl chloride (I) with ethylene in the presence of AlCl3 furnished 1-methyl-1,2,3,4-tetrahydronaphthalen-2-one (II) (1). Subsequent alkylation of the sodium enolate of (II) with N-(2-chloroethyl)piperidine (III) gave rise to the title compound.

参考文献No.	57801
标题:	A process for the preparation of nepinalone
作者:	Tenconi, F.; Furfaro, S.
来源:	EP 0507001

合成路线图解说明: Friedel-Crafts condensation of 2-phenylpropionyl chloride (I) with ethylene in the presence of AlCl3 furnished 1-methyl-1,2,3,4-tetrahydronaphthalen-2-one (II) (1). Subsequent alkylation of the sodium enolate of (II) with N-(2-chloroethyl)piperidine (III) gave rise to the title compound.