【药物名称】Wy-50295 tromethamine
化学结构式(Chemical Structure):
参考文献No.9754
标题:2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents
作者:Kreft, A.F.; Musser, J.H.; Bicksler, J.J.; Giberson, J.W.; Kubrak, D.M. (American Home Products Corp.)
来源:AU 8819209; EP 0301813; GB 2207428; US 5208344
合成路线图解说明:

Alkylation of the disodium salt of the known optically active hydroxyacid (I) with 2-chloromethylquinoline (II) in DMF afforded Wy-50,295 free acid (III). This was reacted with tromethamine in aqueous ethanol to afford the salt (IV).

参考文献No.124498
标题:Determination of the absolute configurations of (+)-2-(6-methoxy-2-naphthyl)propionic acid
作者:Maddox, M.L.; Riegl, J.; Harrison, I.T.
来源:J Med Chem 1974,17377
合成路线图解说明:

Alkylation of the disodium salt of the known optically active hydroxyacid (I) with 2-chloromethylquinoline (II) in DMF afforded Wy-50,295 free acid (III). This was reacted with tromethamine in aqueous ethanol to afford the salt (IV).

参考文献No.140266
标题:Wy-50,295 TROMETHAMINE
作者:Kreft, A.; Musser, J.; Marshall, L.; Grimes, D.
来源:Drugs Fut 1990,15(8),805
合成路线图解说明:

Alkylation of the disodium salt of the known optically active hydroxyacid (I) with 2-chloromethylquinoline (II) in DMF afforded Wy-50,295 free acid (III). This was reacted with tromethamine in aqueous ethanol to afford the salt (IV).

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