【药物名称】Fedotozine tartrate, JO-1196
化学结构式(Chemical Structure):
参考文献No.163860
标题:Fedotozine Tartrate
作者:Homerin, M.; Gen鑦e, J.; Karaus, M.; K鰎ber, J.
来源:Drugs Fut 1992,17(2),101
合成路线图解说明:

Fedotozine (-)-tartrate can be prepared by two different methods: a) Conventional resolution in ethanol of racemic (?-N,N-dimethyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-1-phenyl-n-propylamine with (-)-tartaric acid. b) Condensation of (+)-2-dimethylamino-2-phenyl-n-butanol (I) with 3,4,5-trimethoxybenzyl chloride (II) gives (+)-N,N-dimethyl-1-[(3,4,5-trimethoxybenzyl)oxymethyl]-1-phenyl-n-propylamine, which is salified with (-)-tartaric acid in ethanol to give fedotozine (-)-tartrate.

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