Pyrazoloacridine, PZA, NSC-366140, PD-115934-药物合成数据库

【药物名称】Pyrazoloacridine, PZA, NSC-366140, PD-115934

化学结构式(Chemical Structure):

参考文献No.	1542
标题:	Pyrazolo[3,4,5-kl]acridine cpds., pharmaceutical compsns. the same and processes for their production
作者:	Capps, D.B. (Pfizer Inc.)
来源:	EP 0138302; ES 8701758; ES 8703468; ES 8703874; ES 8703875; JP 1985069084; JP 1994041127; US 4555572

合成路线图解说明: The condensation of 4-methoxyaniline (I) with 2,6-dichloro-3-nitrobenzoic acid (II) by means of DIEA or N,N-dimethylaniline at 75 C gives 6-chloro-2-(4-methoxyphenylamino)-3-nitrobenzoic acid (III), which is cyclized in refluxing POCl3 to yield the acridone (IV). Finally, this compound is condensed with N-[3-(dimethylamino)propyl]hydrazine (V) in THF/methanol to afford the target 2,6-dihydro-pyrazolo[3,4,5-kl]acridine.

参考文献No.	207271
标题:	2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines, a new class of anticancer agents
作者:	Capps, D.B.; Dunbar, J.; Kesten, S.R.; Shillis, J.; Werbel, L.M.; Plowman, J.; Ward, D.L.
来源:	J Med Chem 1992,35(26),4770

合成路线图解说明: The condensation of 4-methoxyaniline (I) with 2,6-dichloro-3-nitrobenzoic acid (II) by means of DIEA or N,N-dimethylaniline at 75 C gives 6-chloro-2-(4-methoxyphenylamino)-3-nitrobenzoic acid (III), which is cyclized in refluxing POCl3 to yield the acridone (IV). Finally, this compound is condensed with N-[3-(dimethylamino)propyl]hydrazine (V) in THF/methanol to afford the target 2,6-dihydro-pyrazolo[3,4,5-kl]acridine.