CDRI-87/144-药物合成数据库

【药物名称】CDRI-87/144

化学结构式(Chemical Structure):

参考文献No.	14139
标题:	5(6)-Benzene ring substd. benzimidazole-2-carbamate derivs. having anthelmintic activity
作者:	Beard, C.C. (Syntex (USA), Inc.)
来源:	US 4086235

合成路线图解说明: The reaction of 4-chloro-3-nitrobenzoic acid (I) with thionyl chloride gives the acid chloride (II) which, by reaction with 4-methylpiperidine, affords the amide (III). Amination of (III) with methanolic ammonia followed by reduction of the nitro group gives the diamine compound (IV), which reacts with 1,3-bis(methoxycarbonyl)-S-methylisothiourea affording CDRI-87-144.

参考文献No.	138380
标题:	CDRI-87-144
作者:	Arya, V.P.
来源:	Drugs Fut 1991,16(5),420

合成路线图解说明: The reaction of 4-chloro-3-nitrobenzoic acid (I) with thionyl chloride gives the acid chloride (II) which, by reaction with 4-methylpiperidine, affords the amide (III). Amination of (III) with methanolic ammonia followed by reduction of the nitro group gives the diamine compound (IV), which reacts with 1,3-bis(methoxycarbonyl)-S-methylisothiourea affording CDRI-87-144.