Ibrolipim, OPF-009, NO-1886-药物合成数据库

【药物名称】Ibrolipim, OPF-009, NO-1886

化学结构式(Chemical Structure):

参考文献No.	13619
标题:	Carboxamide derivs
作者:	Tsutsumi, K.; Uesaka, E.; Shinomiya, K.; Tsuda, Y.; Shoji, Y.; Shima, A. (Otsuka Pharmaceutical Co., Ltd.)
来源:	AU 9056011; EP 0402033; JP 1991068592

合成路线图解说明: By condensation of 4-(chloroformyl)benzylphosphonic acid diethyl ester (I) with 2-amino-5-bromobenzonitrile (II) by means of dimethylaminopyridine (DMAP) and triethylamine in dichloromethane.

参考文献No.	371061
标题:	NO-1886
作者:	Tracy, M.; Casta馿r, J.
来源:	Drugs Fut 1996,21(9),901

合成路线图解说明: By condensation of 4-(chloroformyl)benzylphosphonic acid diethyl ester (I) with 2-amino-5-bromobenzonitrile (II) by means of dimethylaminopyridine (DMAP) and triethylamine in dichloromethane.