Caldaret hydrate, MCC-135-药物合成数据库

【药物名称】Caldaret hydrate, MCC-135

化学结构式(Chemical Structure):

参考文献No.	13315
标题:	Aminobenzenesulfonic acid deriv.
作者:	Okushima, H.; Narimatsu, A.; Kobayashi, M.; Satoh, N.; Morita, M. (Mitsubishi Chemical Corp.)
来源:	EP 0390654; JP 1991007263; US 5053409

合成路线图解说明: The title compound was obtained by condensation between 2-fluoro-5-methylbenzenesulfonic acid (I) and piperazine (II) in the presence of copper powder and cuprous iodide in a sealed tube at 160 C. It was converted to the more stable monohydrate form by suspension of the anhydrous crystals in cold water.

参考文献No.	36683
标题:	Monohydrates of aminobenzenesulfonic acid derivs. and method for preparation thereof
作者:	Yamazaki, C.; Sato, T.; Nagano, T. (Mitsubishi Chemical Corp.)
来源:	EP 0779283; JP 2001316381; US 5990113; US 6245767

合成路线图解说明: The title compound was obtained by condensation between 2-fluoro-5-methylbenzenesulfonic acid (I) and piperazine (II) in the presence of copper powder and cuprous iodide in a sealed tube at 160 C. It was converted to the more stable monohydrate form by suspension of the anhydrous crystals in cold water.