【药物名称】Fudosteine, SS-320A, SS-320, Spelear, Cleanal
化学结构式(Chemical Structure):
参考文献No.11676
标题:Expectorant comprising hydroxy-alkylcysteine deriv
作者:Itoh, Y.; Mizuno, H.; Kiyohara, C.; Sato, S.; Katori, T. (SSP Co., Ltd.)
来源:EP 0346882; EP 0346883; JP 1990003674; US 4906665
合成路线图解说明:

Fudosteine has been obtained by two similar ways: 1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature. 2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.

参考文献No.35879
标题:Preparation method of S-hydroxypropyl-L-cysteine
作者:Ito, Y.; Kuriyama, T.; Ogawa, M.; Sato, S.; Kuraishi, T. (SSP Co., Ltd.)
来源:JP 1996119932
合成路线图解说明:

Fudosteine has been obtained by two similar ways: 1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature. 2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.

参考文献No.453772
标题:Fudosteine
作者:Casta馿r, J.; Leeson, P.; Wroblewski, T.
来源:Drugs Fut 1998,23(4),374
合成路线图解说明:

Fudosteine has been obtained by two similar ways: 1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature. 2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.

参考文献No.456875
标题:The formation of 2-hydroxypropylmercapturic acid from 1-halogenopropanes in the rat
作者:Barnsley, E.A.
来源:Biochem J 1996,100362-72
合成路线图解说明:

Fudosteine has been obtained by two similar ways: 1) By condensation of L-cysteine (I) with 3-bromopropyl alcohol (II) by means of NaOH in water at room temperature. 2) By condensation of L-cysteine (I) with allyl alcohol (III) by means of potassium persulfate in water.

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