【药物名称】KW-3196
化学结构式(Chemical Structure):
参考文献No.13412
标题:Hexitol derivatives having vasodilative activity
作者:Suzuki, F.; Hayashi, H.; Kuroda, T.; Kubo, K.; Ikeda, J. (Kyowa Hakko Kogyo Co., Ltd.)
来源:EP 0393574; JP 1991218381; US 5053408
合成路线图解说明:

The preparation of KW-3196 is as follows: Reaction of 1,4:3,6-dianhydro-D-glucitol 5-methanesulfonate (I) (1) with piperazine (II) afforded (III), which was nitrated with fuming HNO3 to give the nitrate ester (IV). Nicotynoylation of (IV) gave KW-319).

参考文献No.187610
标题:KW-3196
作者:Suzuki, F.
来源:Drugs Fut 1992,17(11),995
合成路线图解说明:

The preparation of KW-3196 is as follows: Reaction of 1,4:3,6-dianhydro-D-glucitol 5-methanesulfonate (I) (1) with piperazine (II) afforded (III), which was nitrated with fuming HNO3 to give the nitrate ester (IV). Nicotynoylation of (IV) gave KW-319).

参考文献No.192901
标题:Synthesis of stereoisomers of 1,4:3,6-dianhydrohexitol nitrate derivative, KF14124
作者:Ueno, H.; Hayashi, H.; Suzuki, F.
来源:Bioorg Med Chem Lett 1992,21187-92
合成路线图解说明:

The preparation of KW-3196 is as follows: Reaction of 1,4:3,6-dianhydro-D-glucitol 5-methanesulfonate (I) (1) with piperazine (II) afforded (III), which was nitrated with fuming HNO3 to give the nitrate ester (IV). Nicotynoylation of (IV) gave KW-319).

参考文献No.900024
标题:Alkylaminodeoxy-1,4:3,6-dianhydrohexitol nitrates substituted by purine bases and their pharmaceutical compositions
作者:Klessing, K.; Chatterjee, S.S. (Dr. Willmar Schwabe)
来源:EP 0044927
合成路线图解说明:

The preparation of KW-3196 is as follows: Reaction of 1,4:3,6-dianhydro-D-glucitol 5-methanesulfonate (I) (1) with piperazine (II) afforded (III), which was nitrated with fuming HNO3 to give the nitrate ester (IV). Nicotynoylation of (IV) gave KW-319).

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