【药物名称】Lufironil, Hoe-077
化学结构式(Chemical Structure):
参考文献No.15584
标题:Pyridine-2,4- and 2,5-dicarboxydi(nitroxyalkyl)amides, processes for their preparation, and their use
作者:Baader, E. (Aventis SA)
来源:DE 4001002; EP 0438795; JP 1992330060
合成路线图解说明:

Lufironil is obtained by treatment of 2,4-pyridinedicarboxylic acid (I) with thionyl chloride in toluene, followed by reaction with 2-methoxyethylamine, either in dioxane (1) or in toluene in the presence of triethylamine.

参考文献No.16123
标题:Improved process of preparation of N,N-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid amides
作者:Baader, E.; Burghard, H.; Bickel, M.; Guenzler-Pukall, V. (Aventis SA)
来源:EP 0353668
合成路线图解说明:

Lufironil is obtained by treatment of 2,4-pyridinedicarboxylic acid (I) with thionyl chloride in toluene, followed by reaction with 2-methoxyethylamine, either in dioxane (1) or in toluene in the presence of triethylamine.

参考文献No.215474
标题:Lufironil
作者:Prous, J.; Casta馿r, J.; Mealy, N.
来源:Drugs Fut 1993,18(8),704
合成路线图解说明:

Lufironil is obtained by treatment of 2,4-pyridinedicarboxylic acid (I) with thionyl chloride in toluene, followed by reaction with 2-methoxyethylamine, either in dioxane (1) or in toluene in the presence of triethylamine.

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