Iobitridol, Xenetix-药物合成数据库

【药物名称】Iobitridol, Xenetix

化学结构式(Chemical Structure):

参考文献No.	15428
标题:	Non-ionic iodinated cpds., procedure for their preparation and contrast agents containing them
作者:	Schaefer, M.; Dugast-Zrihen, M.; Guillemot, M.; Doucet, D.; Meyer, D. (Guerbet SA)
来源:	EP 0437144; WO 9109836

合成路线图解说明: Acylation of 5-amino-2,4,6-triiodoisophthaloyl chloride (I) with 2-isopropyl-1,3-dioxane-5-carbonyl chloride (II) provided the amido isophthaloyl chloride (III). Acid chloride (III) was then condensed with 3-(methylamino)-1,2-propanediol (IV) to furnish the triamide compound (V). The acetal protecting group was finally removed under acidic conditions.

参考文献No.	57819
标题:	Iodinated non-ionic triiodobenzene cpds. and contrast media containing them
作者:	Meyer, D.; Doucet, D.; Guillemot, M.; Dugast-Zrihen, M.; Schaefer, M. (Guerbet SA)
来源:	US 5043152

合成路线图解说明: Acylation of 5-amino-2,4,6-triiodoisophthaloyl chloride (I) with 2-isopropyl-1,3-dioxane-5-carbonyl chloride (II) provided the amido isophthaloyl chloride (III). Acid chloride (III) was then condensed with 3-(methylamino)-1,2-propanediol (IV) to furnish the triamide compound (V). The acetal protecting group was finally removed under acidic conditions.