AN-9, Pivanex-药物合成数据库

【药物名称】AN-9, Pivanex

化学结构式(Chemical Structure):

参考文献No.	16757
标题:	Biologically active carboxylic acid esters
作者:	Nudelman, A.; Shaklai, M.; Rephaeli, A. (Bar-Ilan University)
来源:	EP 0302349; JP 1998152436; JP 1998152454

合成路线图解说明: The title butyric acid prodrug was prepared by condensation of butyric acid (I) with chloromethyl pivalate (II) in the presence of Et3N in acetone.

参考文献No.	175339
标题:	Novel anticancer prodrugs of butyric acid. 2
作者:	Nudelman, A.; Ruse, M.; Aviram, A.; Rabizadeh, E.; Shaklai, M.; Zimrah, Y.; Rephaeli, A.
来源:	J Med Chem 1992,35(4),687

合成路线图解说明: The title butyric acid prodrug was prepared by condensation of butyric acid (I) with chloromethyl pivalate (II) in the presence of Et3N in acetone.