【药物名称】Disalazine, VUFB-17259
化学结构式(Chemical Structure):
参考文献No.166446
标题:Disalazine
作者:Kuchar, M.
来源:Drugs Fut 1992,17(2),98
合成路线图解说明:

Diazotization of 4-[N-(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]aniline (I) by means of sodium nitrite in diluted hydrochloric acid gives a corresponding diazonium salt (II), which is then reacted with salicylic acid (III) to afford the 2-hydroxy intermediate (IV). Disalazine is obtained by the reaction of (IV) with acetic anhydride or acetyl chloride.

参考文献No.900124
标题:5-((4-(4,6-Dimethyl-2-pyrimidinylsulfamoyl)phenyl)azo)acetylsalicylic acid
作者:Kejha, J.; et al.
来源:Czech Appl 1426-91 (1991); Eur Pat Appl 91 117 064.5
合成路线图解说明:

Diazotization of 4-[N-(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]aniline (I) by means of sodium nitrite in diluted hydrochloric acid gives a corresponding diazonium salt (II), which is then reacted with salicylic acid (III) to afford the 2-hydroxy intermediate (IV). Disalazine is obtained by the reaction of (IV) with acetic anhydride or acetyl chloride.

参考文献No.900125
标题:Azo compounds of sulfonamides and hydroxy benzoic acids
作者:Kejha, J.; et al.
来源:Czech. Appl. 6722-87
合成路线图解说明:

Diazotization of 4-[N-(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]aniline (I) by means of sodium nitrite in diluted hydrochloric acid gives a corresponding diazonium salt (II), which is then reacted with salicylic acid (III) to afford the 2-hydroxy intermediate (IV). Disalazine is obtained by the reaction of (IV) with acetic anhydride or acetyl chloride.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us