Entacapone, COM-998, OR-611, Comtess, Comtan-药物合成数据库

【药物名称】Entacapone, COM-998, OR-611, Comtess, Comtan

化学结构式(Chemical Structure):

参考文献No.	8438
标题:	Novel pharmacologically active cpds., their process of preparation and compsns. containing them
作者:	Backstrom, R.J.; Heinola, K.E.; Honkanen, E.J.; Kaakkola, S.K.; Karrisalo, P.J.; Linden, I.-B.Y.; Mannisto, P.T.; Nissinen, E.A.O.; Pohto, P.; Pippuri, A.K.; Pystynen, J.J. (Orion Corporation)
来源:	AU 8781879; BE 1003279; CH 685436; DE 3740383; FR 2607493; GB 2200109; JP 1988170311; US 4963590; US 5112861

合成路线图解说明: Title compound is obtained by reaction of 3,4-dihydroxy-5-nitrobenzaldehyde (I) with N,N-diethyl-2-cyanoacetamide (II) in the presence of piperidine acetate in ethanol.

参考文献No.	258368
标题:	Entacapone
作者:	Casta馿r, J.; Prous, J.; Rabasseda, X.
来源:	Drugs Fut 1994,19(7),641

合成路线图解说明: Title compound is obtained by reaction of 3,4-dihydroxy-5-nitrobenzaldehyde (I) with N,N-diethyl-2-cyanoacetamide (II) in the presence of piperidine acetate in ethanol.