【药物名称】
化学结构式(Chemical Structure):
参考文献No.175869
标题:Synthesis and biological evaluation of a series of gem-dichlorocyclopropanes as antitumor agents
作者:Griffin, M.T.; et al.
来源:Anti-Cancer Drug Des 1992,7(1),49
合成路线图解说明:

By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

参考文献No.228625
标题:Synthesis and biological evaluation of a series of 1,1-dichloro-2,2,3-triaryl cyclopropanes as pure antiestrogens
作者:Day, B.W.; Magarian, R.A.; Jain, P.T.; Pento, J.T.; Mousissian, G.K.; Meyer, K.
来源:J Med Chem 1991,34(2),842-851
合成路线图解说明:

By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

参考文献No.330238
标题:Synthesis and biological evaluation of basic side chain derivatives of Analog II as pure antiestrogens and antitumor agents
作者:Magarian, R.A.; et al.
来源:Anti-Cancer Drug Des 1995,10(4),311
合成路线图解说明:

By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

参考文献No.803820
标题:Synthesis of cyclopropyl analogs of stilbenediol as possible antiestrogens
作者:Benjamin, E.J.; Magarian, R.A.
来源:J Pharm Sci 1975,641626-34
合成路线图解说明:

By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

参考文献No.803821
标题:Synthesis and biological evaluation of gem-dichlorocyclopropyl and cyclopropyl analogs of stilbene congeners as potential antiestrogens
作者:Stobaugh, J.F.; Magarian, R.A.; Pento, J.T.
来源:J Pharmacol Sci 1982,711126-29
合成路线图解说明:

By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

参考文献No.803822
标题:Synthesis of air and light sensitive cis-phenolic cyclopropane derivatives
作者:Afzal, J.; Pento, J.T.; Griffin, M.T.; Magarian, R.A.
来源:Synth Commun 1989,193061-68
合成路线图解说明:

By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

参考文献No.803823
标题:Cyclopropyl antiestrogens: a new class of antitumor agents for the treatment of breast cancer
作者:Pento, J.T.
来源:Drugs Fut 1997,22(6),647
合成路线图解说明:

By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线图解说明:

By a two-phase catalytic cyclopropanation of 4-fluoro-4'-methoxy-cis-stilbene (I) with chloroform, conc. NaOH and triethbenzylammonium chloride (TEBA). Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

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