【药物名称】Pimagedine, Aminoguanidine, YM-585, MDL-201228, GER-11(HCl)
化学结构式(Chemical Structure):
参考文献No.248885
标题:Synthesis of 14C-labelled aminoguanidine
作者:Lo, T.W.C.; Thornalley, P.J.
来源:J Label Compd Radiopharm 1994,34(2),179-83
合成路线图解说明:

The study of the pharmacological effects of pimagedine has required the synthesis of a radiolabeled derivative. [14C]-Pimagedine was synthesized by the reaction of hydrazine sulfate with barium [14C]-cyanamide in a one-step synthesis, and was conveniently isolated by crystallization as the bicarbonate salt.

参考文献No.260664
标题:Pimagedine
作者:Graul, A.; Casta馿r, J.; Prous, J.
来源:Drugs Fut 1994,19(8),740
合成路线图解说明:

The synthesis of pimagedine was first reported more than 100 years ago. Several other preparative methods have since been described. However, the preferred method is the nitration of guanidine nitrate (I) with concentrated sulfuric acid giving nitroguanidine (II), which is then reduced with zinc dust in acetic acid. The title compound is isolated as the bicarbonate salt.

合成路线图解说明:

The study of the pharmacological effects of pimagedine has required the synthesis of a radiolabeled derivative. [14C]-Pimagedine was synthesized by the reaction of hydrazine sulfate with barium [14C]-cyanamide in a one-step synthesis, and was conveniently isolated by crystallization as the bicarbonate salt.

参考文献No.265044
标题:Aminoguanidine bicarbonate
作者:
来源:Org Synth Coll 1967,373
合成路线图解说明:

The synthesis of pimagedine was first reported more than 100 years ago. Several other preparative methods have since been described. However, the preferred method is the nitration of guanidine nitrate (I) with concentrated sulfuric acid giving nitroguanidine (II), which is then reduced with zinc dust in acetic acid. The title compound is isolated as the bicarbonate salt.

参考文献No.700643
标题:
作者:Kurzer, F.; Godfrey, L.E.A.
来源:Chem Ind 1962,1584-95
合成路线图解说明:

The synthesis of pimagedine was first reported more than 100 years ago. Several other preparative methods have since been described. However, the preferred method is the nitration of guanidine nitrate (I) with concentrated sulfuric acid giving nitroguanidine (II), which is then reduced with zinc dust in acetic acid. The title compound is isolated as the bicarbonate salt.

参考文献No.801710
标题:
作者:Thiele, J.
来源:Liebigs Ann Chem 1892,2701
合成路线图解说明:

The synthesis of pimagedine was first reported more than 100 years ago. Several other preparative methods have since been described. However, the preferred method is the nitration of guanidine nitrate (I) with concentrated sulfuric acid giving nitroguanidine (II), which is then reduced with zinc dust in acetic acid. The title compound is isolated as the bicarbonate salt.

参考文献No.801711
标题:
作者:Anzelmi, E.; Smith, G.B.L.
来源:J Am Chem Soc 1935,572730
合成路线图解说明:

The synthesis of pimagedine was first reported more than 100 years ago. Several other preparative methods have since been described. However, the preferred method is the nitration of guanidine nitrate (I) with concentrated sulfuric acid giving nitroguanidine (II), which is then reduced with zinc dust in acetic acid. The title compound is isolated as the bicarbonate salt.

参考文献No.801713
标题:Nitroguanidine
作者:
来源:Org Synth Coll 1967,1399
合成路线图解说明:

The synthesis of pimagedine was first reported more than 100 years ago. Several other preparative methods have since been described. However, the preferred method is the nitration of guanidine nitrate (I) with concentrated sulfuric acid giving nitroguanidine (II), which is then reduced with zinc dust in acetic acid. The title compound is isolated as the bicarbonate salt.

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