【药物名称】Pymadin, Fampridine, 4-Aminopyridine, EL-970, 4-AP, Fampridine-SR, Neurelan
化学结构式(Chemical Structure):
参考文献No.701390
标题:
作者:Koenig, C.; et al.
来源:DE 1270563
合成路线图解说明:

Compound can be prepared in several different ways: 1) By treatment of pyridine-4-sulfonic acid (I) with NH4OH and ZnCl2 in an autoclave at 160 C. 2) By reduction of 4-nitropyridine (II) with SO2 in hot water or diluted H2SO4. 3) By treatment of pyridine-4-carboxylic acid (III) with NH3 at high temperature using CuO as catalyst. 4) By treatment of 4-chloropyridine (IV) or 3-chloropyridine (V) with KNH2 in liquid NH3. 5) By treatment of 4-iodopyridine (VI) or 3-iodopyridine (VII) with KNH2 in liquid NH3.

参考文献No.701391
标题:
作者:Rauch, F.C.; Arzoumanidis, G.G.
来源:US 3812137
合成路线图解说明:

Compound can be prepared in several different ways: 1) By treatment of pyridine-4-sulfonic acid (I) with NH4OH and ZnCl2 in an autoclave at 160 C. 2) By reduction of 4-nitropyridine (II) with SO2 in hot water or diluted H2SO4. 3) By treatment of pyridine-4-carboxylic acid (III) with NH3 at high temperature using CuO as catalyst. 4) By treatment of 4-chloropyridine (IV) or 3-chloropyridine (V) with KNH2 in liquid NH3. 5) By treatment of 4-iodopyridine (VI) or 3-iodopyridine (VII) with KNH2 in liquid NH3.

参考文献No.701392
标题:
作者:Rauch, F.C.; Arzoumanidis, G.G.
来源:DE 2258227
合成路线图解说明:

Compound can be prepared in several different ways: 1) By treatment of pyridine-4-sulfonic acid (I) with NH4OH and ZnCl2 in an autoclave at 160 C. 2) By reduction of 4-nitropyridine (II) with SO2 in hot water or diluted H2SO4. 3) By treatment of pyridine-4-carboxylic acid (III) with NH3 at high temperature using CuO as catalyst. 4) By treatment of 4-chloropyridine (IV) or 3-chloropyridine (V) with KNH2 in liquid NH3. 5) By treatment of 4-iodopyridine (VI) or 3-iodopyridine (VII) with KNH2 in liquid NH3.

参考文献No.701393
标题:
作者:Hayashi, E.; Yamanaka, H.
来源:JP 6115616
合成路线图解说明:

Compound can be prepared in several different ways: 1) By treatment of pyridine-4-sulfonic acid (I) with NH4OH and ZnCl2 in an autoclave at 160 C. 2) By reduction of 4-nitropyridine (II) with SO2 in hot water or diluted H2SO4. 3) By treatment of pyridine-4-carboxylic acid (III) with NH3 at high temperature using CuO as catalyst. 4) By treatment of 4-chloropyridine (IV) or 3-chloropyridine (V) with KNH2 in liquid NH3. 5) By treatment of 4-iodopyridine (VI) or 3-iodopyridine (VII) with KNH2 in liquid NH3.

参考文献No.800479
标题:Reactions of 4-pyridine- and 4-quinolinesulfonic acids with amines
作者:Suzuki, Y.
来源:Yakugaku Zasshi 1961,811146-50
合成路线图解说明:

Compound can be prepared in several different ways: 1) By treatment of pyridine-4-sulfonic acid (I) with NH4OH and ZnCl2 in an autoclave at 160 C. 2) By reduction of 4-nitropyridine (II) with SO2 in hot water or diluted H2SO4. 3) By treatment of pyridine-4-carboxylic acid (III) with NH3 at high temperature using CuO as catalyst. 4) By treatment of 4-chloropyridine (IV) or 3-chloropyridine (V) with KNH2 in liquid NH3. 5) By treatment of 4-iodopyridine (VI) or 3-iodopyridine (VII) with KNH2 in liquid NH3.

参考文献No.800480
标题:Rearrangements during aminations of halopyridines, presumably involving a pyridine intermediate
作者:Pieterse, M.J.; Den Hertog, H.J.
来源:Recl Trav Chim Pays-Bas 1961,801376-86
合成路线图解说明:

Compound can be prepared in several different ways: 1) By treatment of pyridine-4-sulfonic acid (I) with NH4OH and ZnCl2 in an autoclave at 160 C. 2) By reduction of 4-nitropyridine (II) with SO2 in hot water or diluted H2SO4. 3) By treatment of pyridine-4-carboxylic acid (III) with NH3 at high temperature using CuO as catalyst. 4) By treatment of 4-chloropyridine (IV) or 3-chloropyridine (V) with KNH2 in liquid NH3. 5) By treatment of 4-iodopyridine (VI) or 3-iodopyridine (VII) with KNH2 in liquid NH3.

参考文献No.800481
标题:4-Aminopyridine
作者:Serradell, M.N.; Blancafort, P.; Casta馿r, J.; Paton, D.M.
来源:Drugs Fut 1980,5(5),221
合成路线图解说明:

Compound can be prepared in several different ways: 1) By treatment of pyridine-4-sulfonic acid (I) with NH4OH and ZnCl2 in an autoclave at 160 C. 2) By reduction of 4-nitropyridine (II) with SO2 in hot water or diluted H2SO4. 3) By treatment of pyridine-4-carboxylic acid (III) with NH3 at high temperature using CuO as catalyst. 4) By treatment of 4-chloropyridine (IV) or 3-chloropyridine (V) with KNH2 in liquid NH3. 5) By treatment of 4-iodopyridine (VI) or 3-iodopyridine (VII) with KNH2 in liquid NH3.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us