【药物名称】Colestilan, Colestimide, MCI-196, Cholebine
化学结构式(Chemical Structure):
参考文献No.20606
标题:Oral hypocholesterolemic agents
作者:Nomura, T.; Hamada, Y.; Kurihara, Y. (Mitsubishi Chemical Corp.)
来源:JP 1992013627
合成路线图解说明:

MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows: Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C. The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more. Finally, heat curing of the resin at 120 C for 5 h was performed. The resin was isolated by precipitation with water.

参考文献No.20607
标题:Oral hypocholesterolemic agents
作者:Nomura, T.; Hamada, Y.; Kurihara, Y. (Mitsubishi Chemical Corp.)
来源:JP 1990124819
合成路线图解说明:

MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows: Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C. The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more. Finally, heat curing of the resin at 120 C for 5 h was performed. The resin was isolated by precipitation with water.

参考文献No.20608
标题:Process for the preparation of granular basic ion exchange resins
作者:Toda, H. (Mitsubishi Chemical Corp.)
来源:JP 1985245626
合成路线图解说明:

MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows: Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C. The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more. Finally, heat curing of the resin at 120 C for 5 h was performed. The resin was isolated by precipitation with water.

参考文献No.20609
标题: Improved preparation process for anion exchange resins
作者:Toda, H.; Kihara, K. (Mitsubishi Chemical Corp.)
来源:JP 1984155421
合成路线图解说明:

MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows: Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C. The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more. Finally, heat curing of the resin at 120 C for 5 h was performed. The resin was isolated by precipitation with water.

参考文献No.20610
标题:Novel quaternary salt of polymer
作者:Toda, H.; Kihara, K. (Bristol-Myers Squibb Co.)
来源:BE 0898807; CH 663415; DE 3403125; GB 2134119; NL 8400237
合成路线图解说明:

MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows: Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C. The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more. Finally, heat curing of the resin at 120 C for 5 h was performed. The resin was isolated by precipitation with water.

参考文献No.185166
标题:Bile acid binding and hypocholesterolemic activity of a new anion exchange resin from 2-methylimidazol and epichlorohydrin
作者:Toda, H.; Kihara, K.; Hashimoto, M.; Mizogami, S.
来源:J Pharm Sci 1988,77(6),531
合成路线图解说明:

MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows: Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C. The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more. Finally, heat curing of the resin at 120 C for 5 h was performed. The resin was isolated by precipitation with water.

参考文献No.195097
标题:MCI-196
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1993,18(1),15
合成路线图解说明:

MCI-196 is synthesized by condensation of 2-methylimidazole (I) with epichlorohydrin (II) as follows: Equimolecular parts (0.5 M: 0.5 M) of (I) and (II) were allowed to condense in water (100 ml) at 90 C for 14 h; then 0.094 mol of (II) wa added and the reaction continued for 2 h at 45 C. The resulting resin was treated with 0.094 M of a 20% aqueous solution of NaOH and heated at 45 C for 2 h more. Finally, heat curing of the resin at 120 C for 5 h was performed. The resin was isolated by precipitation with water.

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