Ibandronate sodium hydrate, Ibandronic acid monosodium salt monohydrate, Ro-200-5450, R-484, RPR-102289A, BM-21.0955 monosodium salt monohydrate, Boniva, Destara, Bonviva(former Brand Name), Bondronat-药物合成数据库

【药物名称】Ibandronate sodium hydrate, Ibandronic acid monosodium salt monohydrate, Ro-200-5450, R-484, RPR-102289A, BM-21.0955 monosodium salt monohydrate, Boniva, Destara, Bonviva(former Brand Name), Bondronat

化学结构式(Chemical Structure):

参考文献No.	234806
标题:	BM-21.0955, Monosodium Salt, Monohydrate
作者:	M黨lbauer, R.C.; Bauss, F.
来源:	Drugs Fut 1994,19(1),13

合成路线图解说明: Starting from N-pentylamine (I), the intermediate N-methyl-N-pentylamine (IV) is condensed with methyl methacrylate to give N-methyl-N-pentyl-beta-alanine methyl ester (V). After hydrolysis of the methyl ester (V), the bisphosphonate is produced in the common way using phosphorous oxychloride/phosphorous acid.