【药物名称】SS-212
化学结构式(Chemical Structure):
参考文献No.18337
标题:Novel benzo[5,6]cyclohepta[1,2-b]pyridine derivs. and antiallergic agents comprising same
作者:Honda, H.; Mizuno, H.; Mogi, K.; Ito, Y.; Kaneko, Y.; Taido, N.; Sato, S.; Kuraishi, T. (SSP Co., Ltd.)
来源:EP 0495484; JP 1993059040; US 5231101
合成路线图解说明:

The known tricyclic bromide (I) was converted to the nitrile (II) by treatment with CuCN and NaCN. Addition of the Grignard reagent (IV), prepared from 4-chloro-1-methylpiperidine (III), to the tricyclic ketone (II) furnished the tertiary alcohol (V). This was finally dehydrated to the target piperidylidene derivative upon heating in the presence of SOCl2.

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