【药物名称】Bisnafide mesylate, Bisnafide mesilate, NSC-D640430, DMP-840
化学结构式(Chemical Structure):
参考文献No.18819
标题:Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
作者:Sun, J.-H. (DuPont Pharmaceuticals Co.)
来源:EP 0506008; EP 0577753; JP 1994506229; US 5206249; WO 9217453
合成路线图解说明:

The condensation of tert-butoxycarbonyl-D-alanine (I) with ethylenediamine (II) gives the corresponding protected diamide (III), which is deprotected in acidic medium to the diamide (IV). The reduction of (IV) with diborane in THF yields the (R,R)-4,7-diazadecane-2,9-diamine (V), which is finally condensed with 3-nitronaphthalene-1,8-dicarboxylic acid anhydride (VI) in refluxing ethanol and salified with methanesulfonic acid.

参考文献No.345057
标题:Bisnafide Mesylate
作者:Robinson, C.P.; Robinson, K.A.; Casta馿r, J.
来源:Drugs Fut 1996,21(3),239
合成路线图解说明:

The condensation of tert-butoxycarbonyl-D-alanine (I) with ethylenediamine (II) gives the corresponding protected diamide (III), which is deprotected in acidic medium to the diamide (IV). The reduction of (IV) with diborane in THF yields the (R,R)-4,7-diazadecane-2,9-diamine (V), which is finally condensed with 3-nitronaphthalene-1,8-dicarboxylic acid anhydride (VI) in refluxing ethanol and salified with methanesulfonic acid.

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