【药物名称】BMS-181184
化学结构式(Chemical Structure):
参考文献No.15162
标题:Pradimicin derivs
作者:Aburaki, S.; Yamasaki, T.; Oki, T.; Iimura, S.; Kamachi, H.; Kamei, H.; Naito, T. (Bristol-Myers Squibb Co.)
来源:EP 0432527; JP 1991170493; US 5410029
合成路线图解说明:

The oxidation of pradimicin FA-2 (I) with 3,5-di-tert-butyl-1,2-benzoquinone (DBBQ) according to Corey's method gives the corresponding imine (II), which by hydrolysis with formic acid is converted into the 4'-deamino-4'-oxo derivative (III). Finally, this compound is reduced with NaBH4 in water yielding the mixture of the 4'-hydroxy epimers, which is separated by HPLC chromatography.

参考文献No.199385
标题:Synthesis and antifungal activities of pradimicin derivatives, modification at C4'-position
作者:Kamachi, H.; Iimura, S.; Okuyama, S.; Hoshi, H.; Tamura, S.; Shinoda, M.; Saitoh, K.; Konishi, M.; Oki, T.
来源:J Antibiot 1992,45(9),1518-25
合成路线图解说明:

The oxidation of pradimicin FA-2 (I) with 3,5-di-tert-butyl-1,2-benzoquinone (DBBQ) according to Corey's method gives the corresponding imine (II), which by hydrolysis with formic acid is converted into the 4'-deamino-4'-oxo derivative (III). Finally, this compound is reduced with NaBH4 in water yielding the mixture of the 4'-hydroxy epimers, which is separated by HPLC chromatography.

参考文献No.311633
标题:BMS-181184
作者:Fromtling, R.A.; Casta馿r, J.
来源:Drugs Fut 1995,20(9),876
合成路线图解说明:

The oxidation of pradimicin FA-2 (I) with 3,5-di-tert-butyl-1,2-benzoquinone (DBBQ) according to Corey's method gives the corresponding imine (II), which by hydrolysis with formic acid is converted into the 4'-deamino-4'-oxo derivative (III). Finally, this compound is reduced with NaBH4 in water yielding the mixture of the 4'-hydroxy epimers, which is separated by HPLC chromatography.

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