【药物名称】Levosimendan, (-)-OR-1259, Simdax
化学结构式(Chemical Structure):
参考文献No.13010
标题:Heterocyclic cpds.
作者:Haikala, H.O.; Nore, P.T.; Honkanen, E.J.; Pystynen, J.J.; L鰊nberg, K.K.; Luiro, A.M.; Pippuri, A.K. (Orion Corporation)
来源:EP 0383449; JP 1990288868; US 5019575; US 5122524; US 5185332
合成路线图解说明:

The optical resolution of 6-(4-aminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one (I) with L-tartaric acid in isopropanol or D-tartaric acid in ethyl acetate gives the (R)-enantiomer (II), which is then condensed with malonodinitrile (III) by means of NaNO2 and HCl in cool water.

参考文献No.18223
标题:Pyridazine deriv.
作者:B鋍kstr鰉, R.J.; Haarala, J.V.; Honkanen, E.J.; Nore, P.T.; Wikberg, T.E.I.; Haikala, H.O. (Orion Corporation)
来源:GB 2251615; JP 1994504275; US 5424428; US 5512571; US 5569657; WO 9212135
合成路线图解说明:

The optical resolution of 6-(4-aminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one (I) with L-tartaric acid in isopropanol or D-tartaric acid in ethyl acetate gives the (R)-enantiomer (II), which is then condensed with malonodinitrile (III) by means of NaNO2 and HCl in cool water.

参考文献No.43511
标题:Method for obtaining pure enantiomers of a pyridazinone deriv.
作者:Tanninen, V.P.; Timmerbacka, M.; Kaukonen, J.; Lehtonen, J.; Hypp鰈? R.; Muttonen, E. (Orion Corporation)
来源:WO 9735841
合成路线图解说明:

The optical resolution of 6-(4-aminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one (I) with L-tartaric acid in isopropanol or D-tartaric acid in ethyl acetate gives the (R)-enantiomer (II), which is then condensed with malonodinitrile (III) by means of NaNO2 and HCl in cool water.

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