S-9788-药物合成数据库

【药物名称】S-9788

化学结构式(Chemical Structure):

参考文献No.	199381
标题:	New triazine derivatives as potent modulators of multidrug resistance
作者:	Dhainaut, A.; R間nier, G.; Atassi, G.; Pierr? A.; L閛nce, S.; Kraus-Berthier, L.; Prost, J.F.
来源:	J Med Chem 1992,35(13),2481-96

合成路线图解说明: The 1-[4,6-bis(allylamino)-1,3,5-triazin-2-yl]-4-piperidone hydrochloride (I) is added to [bis(4-fluorophenyl)methyl]amine (II) in dry methanol. The solution is acidified to pH 6 before adding NaBH3CN, resulting in 6-[4-[2,2-di-(4-fluorophenyl)ethylamino]piperidin-1-yl]-N,N'-diallyl-1,3,5-triazine-2,4-diamine (III). Treatment of (III) with methanesulfonic acid in isopropanol gives the bismethanesulfonate salt.

参考文献No.	214282
标题:	S9788
作者:	Mazier, B.; Berille, J.; Sarkany, M.; G閞ard, B.; Lucas, C.; Paraire, M.; Berlion, M.; Bizzari, J.P.; Giroux, B.
来源:	Drugs Fut 1993,18(8),711

合成路线图解说明: The 1-[4,6-bis(allylamino)-1,3,5-triazin-2-yl]-4-piperidone hydrochloride (I) is added to [bis(4-fluorophenyl)methyl]amine (II) in dry methanol. The solution is acidified to pH 6 before adding NaBH3CN, resulting in 6-[4-[2,2-di-(4-fluorophenyl)ethylamino]piperidin-1-yl]-N,N'-diallyl-1,3,5-triazine-2,4-diamine (III). Treatment of (III) with methanesulfonic acid in isopropanol gives the bismethanesulfonate salt.