The reaction of meclofenamic acid (I) with oxalyl chloride in dichloromethane gives the corresponding acyl chloride (II), which by reaction with methanol yields the methyl ester (III). The reduction of (III) with LiAlH4 in THF affords the methanol derivative (IV), which by oxidation with pyridinium chlorochromate (PCC) is converted into the aldehyde (V). Finally, this compound is condensed with 2-thioxothiazolidin-4-one (VI) by means of beta-alanine in refluxing acetic acid.