Talsaclidine fumarate, WAL-2014-FU-药物合成数据库

【药物名称】Talsaclidine fumarate, WAL-2014-FU

化学结构式(Chemical Structure):

参考文献No.	12524
标题:	Novel quinuclidines, their pharmaceutical use and process for their preparation
作者:	Walther, G.; Weber, K.-H.; Stransky, W.; Kuhn, F.; M黮ler, E.; Ensinger, H. (Boehringer Ingelheim GmbH)
来源:	AU 8945403; DE 3839385; EP 0370415; JP 1990243688; US 5286864; US 5451587

合成路线图解说明: The condensation of 3-hydroxy-1-azabicyclo[2.2.2]octan borane complex (I) with 2-propynyl bromide (II) by means of NaH in DMF gives racemic 3-(2-propynyloxy)-1-azabicyclo[2.2.2]octane (III), which is then submitted to optical resolution with (+)- or (-)-dibenzoyltartaric acid. The optically pure tartrates are treated with aqueous K2CO3 and finally with fumaric acid to obtain the optically pure fumarates.

参考文献No.	235074
标题:	WAL-2014-FU
作者:	Mealy, N.; Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1994,19(1),35

合成路线图解说明: The condensation of 3-hydroxy-1-azabicyclo[2.2.2]octan borane complex (I) with 2-propynyl bromide (II) by means of NaH in DMF gives racemic 3-(2-propynyloxy)-1-azabicyclo[2.2.2]octane (III), which is then submitted to optical resolution with (+)- or (-)-dibenzoyltartaric acid. The optically pure tartrates are treated with aqueous K2CO3 and finally with fumaric acid to obtain the optically pure fumarates.