【药物名称】Gadoversetamide, Gd-DTPA-bismethoxyethylamide, MP-1177-10, OptiMARK
化学结构式(Chemical Structure):
参考文献No.57070
标题:Novel magnetic resonance imaging agents
作者:Periasamy, M.P.; Weber, R.W. (Mallinckrodt Medical Inc.)
来源:WO 9001024
合成路线图解说明:

The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II), which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV). Finally, this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.

参考文献No.57071
标题:Process for manufacturing DTPA-bis amide magnetic resonance imaging
作者:White, D.H.; Moore, D.A.; deLearie, L.; Lin, W.H. (Mallinckrodt Medical Inc.)
来源:US 5508388
合成路线图解说明:

The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II), which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV). Finally, this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.

参考文献No.213875
标题:Synthesis and characterization of nonionic paramagnetic metal complexes as potential magnetic resonance imaging contrast agents
作者:White, D.H.; Rajagopalan, R.; Kuan, K.T.; Lin, Y.; Wallace, R.A.; Rogic, M.M.; Bosworth, M.E.; Robbins, M.S.; Ralston, W.H.; Adams, M.D.; et al.
来源:Invest Radiol 1990,25(Suppl. 1),S56
合成路线图解说明:

The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II), which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV). Finally, this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.

参考文献No.214622
标题:The synthesis and screening of nonionic gadolinium (III) DTPA-bisamide complexes as magnetic resonance imaging contrast agents
作者:Periasamy, M.; White, D.H.; deLearie, L.; Moore, D.; Wallace, R.A.; Lin, W.; Dunn, J.P.; Hirth, W.; Cacheris, W.P.; Pilcher, G.; et al.
来源:Invest Radiol 1991,26(Suppl. 1),S217
合成路线图解说明:

The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II), which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV). Finally, this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.

参考文献No.694635
标题:Preparation, physico-chemical characterization, and relaxometry studies of various gadolinium(III)-DTPA-bis(amide) derivatives as potential magnetic resonance contrast agents
作者:Geraldes, C.F.G.C.; Urbano, A.M.; Alpoim, M.C.; Sherry, A.D.; Kuan, K.T.; Rajagopalan, R.; Maton, F.; Muller, R.N.
来源:Magn Reson Imaging 1995,13(3),401
合成路线图解说明:

The reaction of diethylenetriamine-pentaacetic acid (I) with acetic anhydride in hot pyridine gives the dianhydride (II), which is treated with 2-methoxyethylamine (III) in hot acetonitrile or isopropanol to yield the diamide ligand (IV). Finally, this compound is treated with Gd2O3 in hot water/isopropanol/acetonitrile or other mixed solvents to afford the target gadolinium complex.

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