Nicanartine, MRZ-3/124-药物合成数据库

【药物名称】Nicanartine, MRZ-3/124

化学结构式(Chemical Structure):

参考文献No.	21329
标题:	New BHT ether cpds. and their use as hypolipidemic and antiatherosclerotic drugs
作者:	Gold, M.R.; Jarglis, P.; Junglas, H.; Leimner, J.H.; Peteri, D.; Quack, G.P.; Strohmeier, J.; W黮froth, P.M. (Merz & Co. GmbH)
来源:	EP 0619807; JP 1995502271; US 5254549; WO 9312089

合成路线图解说明: Nicanartine is readily accessible by a direct ether coupling reaction of 3-(hydroxymethyl)pyridine (IV) with 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl mesylate (III) under classical Williams-type reaction conditions. 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propyl mesylate (III) in turn is prepared in good yields by a straightforward two-step reaction sequence (reduction, mesylation), starting from the commercially available antioxidant methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate (I) (Ionox 520(TM)).

参考文献No.	300784
标题:	Nicanartine
作者:	W黮froth, P.
来源:	Drugs Fut 1995,20(6),572

合成路线图解说明: Nicanartine is readily accessible by a direct ether coupling reaction of 3-(hydroxymethyl)pyridine (IV) with 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl mesylate (III) under classical Williams-type reaction conditions. 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propyl mesylate (III) in turn is prepared in good yields by a straightforward two-step reaction sequence (reduction, mesylation), starting from the commercially available antioxidant methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate (I) (Ionox 520(TM)).