XE-991-药物合成数据库

【药物名称】XE-991

化学结构式(Chemical Structure):

参考文献No.	12745
标题:	alpha,alpha-Disubstd. aromatics and heteroaromatics as cognition enhancers
作者:	Earl, R.A.; Myers, M.J.; Nickolson, V.J. (DuPont Pharmaceuticals Co.)
来源:	EP 0311010; US 5173489

合成路线图解说明: The title compound was prepared by alkylation of anthrone (I) with 4-picolyl chloride (II) in the presence of an alkaline hydroxide and a phase-transfer catalyst.

参考文献No.	482124
标题:	Acetylcholine release enhancers related to linopirdine: A structure-activity relationship study. II
作者:	Drummond, S.; Wilkerson, W.W.; Calabrese, J.C.; Earl, R.A.; Teleha, C.A.; Zaczek, R.; Voss, M.E.
来源:	Eur J Med Chem 1996,31(4),319

合成路线图解说明: The title compound was prepared by alkylation of anthrone (I) with 4-picolyl chloride (II) in the presence of an alkaline hydroxide and a phase-transfer catalyst.