D-21151-药物合成数据库

【药物名称】D-21151

化学结构式(Chemical Structure):

参考文献No.	20790
标题:	Phthalazines substd. on position 1 by an ether or a thioether group and process for their preparation
作者:	Scheffler, G.; Fleischhauser, I.; Kutscher, B.; Engel, J.; Szelenyi, S.; Werner, U. (Asta Medica AG)
来源:	DE 4234933; EP 0539805; JP 1993222002

合成路线图解说明: D-21151 is easily obtained by a two-step sequence starting from phthalazin-1-one (I). The treatment of (I) with phosphorus oxychloride furnishes 1-chlorophthalazine (II), which is reacted with phenol in the presence of sodium hydride to give D-21151.

参考文献No.	231242
标题:	D-21151
作者:	Engel, J.; Fleischhauer, I.; Scheffler, G.; Werner, U.; Kutscher, B.; Szelenyi, I.
来源:	Drugs Fut 1993,18(12),1107

合成路线图解说明: D-21151 is easily obtained by a two-step sequence starting from phthalazin-1-one (I). The treatment of (I) with phosphorus oxychloride furnishes 1-chlorophthalazine (II), which is reacted with phenol in the presence of sodium hydride to give D-21151.