S-20928-药物合成数据库

【药物名称】S-20928

化学结构式(Chemical Structure):

参考文献No.	476357
标题:	Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands
作者:	Leclerc, V.; Fourmaintraux, E.; Depreux, P.; Lesieur, D.; Morgan, P.; Howell, H.E.; Renard, P.; Caignard, D.H.; Pfeiffer, B.; Delagrange, P.; Guardiola-Lemaitre, B.; Andrieux, J.
来源:	Bioorg Med Chem 1998,6(10),1875

合成路线图解说明: Reduction of 1-naphthylacetonitrile (1) by catalytic hydrogenation using Raney Nickel in a NH3 saturated EtOH solution afforded 2-(1-naphthyl)ethylamine, which was then converted to hydrochloride salt (II). Further condensation with cyclobutanecarbonyl chloride (III) in the presence of K2CO3 provided the target amide.