The synthesis of LY-307853 (the phosphate prodrug of LY-303366) has been performed: The phosphorylation of LY-303366 (I) with tetrabenzyl pyrophosphate (II) by means of LiOH in DMF gives dibenzyl phosphate (III), which is finally debenzylated by hydrogenation with H2 over Pd/C in the presence of sodium acetate.