SCA-40-药物合成数据库

【药物名称】SCA-40

化学结构式(Chemical Structure):

参考文献No.	543512
标题:	New imidazol[1,2-a]pyrazine derivatives withbronchodilatory and cyclic nucleotide phosphodiesterase inhibitory activities
作者:	Vitse, O.; Laurent, F.; Pocock, T.M.; Benezech, V.; Zanik, L.; Elliott, K.R.; Subra, G.; Portet, K.; Bompart, J.; Chapat, J.P.; Small, R.C.; Michel, A.; Bonnet, P.A.
来源:	Bioorg Med Chem 1999,7(6),1059

合成路线图解说明: The precursor imidazopyrazine (III) was prepared by condensation of 2-amino-3,5-dibromopyrazine (I) with ethyl 3-bromopyruvate (II). Subsequent treatment of ester (III) with aqueous ammonia produced the corresponding amide (IV). This was then dehydrated with phosphoryl chloride, with concomitant displacement of the 8-bromine for a chloro group, to yield nitrile (V). Finally, substitution of the chloride by methyl amine in (V) furnished the target compound.

参考文献No.	555590
标题:	Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties
作者:	Sablayrolles, C.; Cros, G.H.; Milhavet, J.C.; Rechenq, E.; Chapat, J.P.; Boucard, M.; Serrano, J.J.; McNeill, J.H.
来源:	J Med Chem 1984,27(2),206

合成路线图解说明: The precursor imidazopyrazine (III) was prepared by condensation of 2-amino-3,5-dibromopyrazine (I) with ethyl 3-bromopyruvate (II). Subsequent treatment of ester (III) with aqueous ammonia produced the corresponding amide (IV). This was then dehydrated with phosphoryl chloride, with concomitant displacement of the 8-bromine for a chloro group, to yield nitrile (V). Finally, substitution of the chloride by methyl amine in (V) furnished the target compound.