Benatoprazole, Tenatoprazole, TU-199, Ulsacare, Protop-药物合成数据库

【药物名称】Benatoprazole, Tenatoprazole, TU-199, Ulsacare, Protop

化学结构式(Chemical Structure):

参考文献No.	7653
标题:	Imidazo[4,5-b]pyridine cpds., process for preparing same and pharmaceutical compsns. containing same
作者:	Matsuichi, N.; Takeda, H.; Iizumi, K.; Murakami, K.; Hisamitsu, A. (Tokyo Tanabe Co., Ltd.)
来源:	AU 8775628; EP 0254588; JP 1988146882

合成路线图解说明: The condensation of 2-mercapto-5-methoxy-3H-imidazo[4,5-b]pyridine (I) with 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine (II) by means of KOH in refluxing ethanol gives 2-(4-methoxy-3,5-dimethylpyridin-2-ylmethylthio)-5-methoxy-3H-imidazo [4,5-b]pyridine (III), which is then oxidized with m-chloroperbenzoic acid in chloroform.

参考文献No.	268559
标题:	TU-199
作者:	Mealy, N.; Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1994,19(11),1018

合成路线图解说明: The condensation of 2-mercapto-5-methoxy-3H-imidazo[4,5-b]pyridine (I) with 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine (II) by means of KOH in refluxing ethanol gives 2-(4-methoxy-3,5-dimethylpyridin-2-ylmethylthio)-5-methoxy-3H-imidazo [4,5-b]pyridine (III), which is then oxidized with m-chloroperbenzoic acid in chloroform.