【药物名称】Mitemcinal fumarate, GM-611
化学结构式(Chemical Structure):
参考文献No.22695
标题:Erythromycin derivs
作者:Koga, H.; Sato, T.; Takanashi, H. (Chugai Pharmaceutical Co. Ltd.)
来源:EP 0643068; JP 1994056873; US 5658888; WO 9324509
合成路线图解说明:

The oxidation of 2'-O-acetyl-4''-O-formyl-8,9-didehydroerythromycin A 6,9-hemiacetal (I) gives the corresponding 11-oxo derivative (II), which was first methylated with NaH and methyl iodide and then hydrolyzed with NaHCO3 to yield 11-deoxy-12-O-methyl-1-oxo-8,9-didehydroerythromycin A 6,9-hemiacetal (III). The demethylation of (III) with I2 and NaOH affords the 3'-N-demethyl derivative (IV), which is finally alkylated with isopropyl iodide and diisopropylethylamine in methanol.

参考文献No.267652
标题:GM-611
作者:Graul, A.; Casta馿r, J.; Prous, J.
来源:Drugs Fut 1994,19(10),910
合成路线图解说明:

The oxidation of 2'-O-acetyl-4''-O-formyl-8,9-didehydroerythromycin A 6,9-hemiacetal (I) gives the corresponding 11-oxo derivative (II), which was first methylated with NaH and methyl iodide and then hydrolyzed with NaHCO3 to yield 11-deoxy-12-O-methyl-1-oxo-8,9-didehydroerythromycin A 6,9-hemiacetal (III). The demethylation of (III) with I2 and NaOH affords the 3'-N-demethyl derivative (IV), which is finally alkylated with isopropyl iodide and diisopropylethylamine in methanol.

参考文献No.604454
标题:Gastrointestinal motor-stimulating activity of macrolide antibiotics and analysis of their side effects on the canine gut
作者:Itoh, Z.; Suzuki, T.; Nakaya, M.; Inoue, M.; Mitsuhashi, S.
来源:Antimicrob Agents Chemother 1984,26(6),863-9
合成路线图解说明:

The oxidation of 2'-O-acetyl-4''-O-formyl-8,9-didehydroerythromycin A 6,9-hemiacetal (I) gives the corresponding 11-oxo derivative (II), which was first methylated with NaH and methyl iodide and then hydrolyzed with NaHCO3 to yield 11-deoxy-12-O-methyl-1-oxo-8,9-didehydroerythromycin A 6,9-hemiacetal (III). The demethylation of (III) with I2 and NaOH affords the 3'-N-demethyl derivative (IV), which is finally alkylated with isopropyl iodide and diisopropylethylamine in methanol.

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