【药物名称】R-91650
化学结构式(Chemical Structure):
参考文献No.22339
标题:Aminoquinolone derivs. as anti-HIV agents
作者:Kimura, T.; Katsube, T. (Ube Industries, Ltd.)
来源:EP 0572259; JP 1994116241; US 5519016; US 5688791
合成路线图解说明:

Quinolinecarboxylic acid (I) was treated with boron trifluoride etherate in refluxing methyl isobutyl ketone to produce the boron chelate (II). Subsequent displacement of the 7-fluoro group of (II) by 1-(2-pyrimidinyl)piperazine (III) furnished adduct (IV). The boron chelate was finally removed by refluxing with triethylamine in methanol.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us