-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	604692
标题:	Phosphonates and thiophosphonates as sulfate surrogates: Synthesis of estrone 3-methylthiophosphonate a potent inhibitor of estrone sulfatase
作者:	Reed, M.J.; Potter, B.V.L.; Purohit, A.; Howarth, N.M.; Cooper, G.; Duncan, L.J.
来源:	Bioorg Med Chem Lett 1993,3(2),313-318

合成路线图解说明: By esterification of 5,6,7,8-tetrahydronaphthalen-2-ol (I) with chlorosulfonamide (II) and NaH in DMF.

合成路线图解说明: By esterification of estrone (I) with chlosulfonamide (II) and NaH in DMF.

参考文献No.	803835
标题:	Steroid sulphatase inhibitors: a new endocrine therapy
作者:	Potter, B.V.L.; Howarth, N.M.; Purohit, A.; Reed, M.J.
来源:	Drugs Fut 1994,19(7),673

合成路线图解说明: By esterification of 5,6,7,8-tetrahydronaphthalen-2-ol (I) with chlorosulfonamide (II) and NaH in DMF.

合成路线图解说明: By esterification of estrone (I) with chlosulfonamide (II) and NaH in DMF.