Meluadrine tartrate, Tulobuterol-(R), (R)-Tulobuterol, HSR-81(R)-药物合成数据库

【药物名称】Meluadrine tartrate, Tulobuterol-(R), (R)-Tulobuterol, HSR-81(R)

化学结构式(Chemical Structure):

参考文献No.	14499
标题:	Optically active benzyl alcohol cpd. and the use thereof
作者:	Ito, Y.; Kato, H.; Koshinaka, E.; Kurata, S.; Morikawa, K. (Abbott Japan)
来源:	EP 0420120; JP 1992178356

合成路线图解说明: Oxidation of 2-chloro-5-hydroxyacetophenone (I) with selenium dioxide gave the phenylglyoxal derivative (II). This was subjected to reductive amination with tert-butylamine in the presence of NaBH4 to afford the racemic amino alcohol (III). After conversion of amino alcohol (III) to the L-tartrate salt, several recrystallizations from methanol-acetone provided the pure (R) enantiomer

参考文献No.	56915
标题:	Hydroxyl-substd. 2-chloro-alpha-(tert-butylaminomethyl)-benzylalcohols
作者:	Yamamoto, Y.; Kato, H.; Kurata, S.; Nishide, K. (Abbott Japan)
来源:	US 4018818

合成路线图解说明: Oxidation of 2-chloro-5-hydroxyacetophenone (I) with selenium dioxide gave the phenylglyoxal derivative (II). This was subjected to reductive amination with tert-butylamine in the presence of NaBH4 to afford the racemic amino alcohol (III). After conversion of amino alcohol (III) to the L-tartrate salt, several recrystallizations from methanol-acetone provided the pure (R) enantiomer