【药物名称】Tetrindol, Tetrindole, Tetrindol
化学结构式(Chemical Structure):
参考文献No.435685
标题:Tetrindole
作者:Glushkov, R.G.; Mashkovsky, M.D.; Andrejeva, N.I.
来源:Drugs Fut 1997,22(12),1333
合成路线图解说明:

The reaction of 6-cyclohexyl-3,4-dihydro-2H-carbazol-1-one (I) with 2-dibenzylaminoethyl chloride by means of phase transfer catalysis using benzyltriethylammonium chloride and sodium hydroxide in chlorobenzene gives 6-cyclohexyl-9-[2-(dibenzylamino)ethyl-3,4-dihydro-2H-carbazol-1-one (II), which is reduced with H2 over palladium bis(acetonylacetonate) and carbon to give tetrindol.

参考文献No.452790
标题:Design of new synthetic drugs: State of the art and prospects
作者:Glushkov, R.G.
来源:Vestn Russ Acad Med Sci 1994,1131-5
合成路线图解说明:

The reaction of 6-cyclohexyl-3,4-dihydro-2H-carbazol-1-one (I) with 2-dibenzylaminoethyl chloride by means of phase transfer catalysis using benzyltriethylammonium chloride and sodium hydroxide in chlorobenzene gives 6-cyclohexyl-9-[2-(dibenzylamino)ethyl-3,4-dihydro-2H-carbazol-1-one (II), which is reduced with H2 over palladium bis(acetonylacetonate) and carbon to give tetrindol.

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