【药物名称】PNU-96988, U-96988
化学结构式(Chemical Structure):
参考文献No.803817
标题:Analogs of 4-hydroxypyrone: potent, non-peptidic HIV protease inhibitors
作者:Romines, K.R.; Thaisrivongs, S.
来源:Drugs Fut 1995,20(4),377
合成路线图解说明:

The condensation of 4-hydroxy-6-methyl-2H-pyran-2-one (I) with 1-phenyl-1-propanol (II) by means of TsOH in toluene gives 4-hydroxy-6-methyl-3-(1-phenyl-propyl)-2H-pyran-2-one (III), which is alkylated with benzyl bromide and LDA in THF yielding 4-hydroxy-6-(2-phenylethyl)-3-(1-phenylpropyl)-2H-pyran-2-one (V). Finally this compound is submitted to a new alkylation process with ethyl iodide and LDA in THF to afford the target compound.

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